Katia Karalis
Adjunct Research Professor Disease Mechanisms and Drug Discovery
N/A
N/A
School of Medicine
Adjunct Research Faculty
Academic Qualifications
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Academic qualifications (list by highest qualification) |
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Qualification |
Year |
Awarding Institution |
Department |
Thesis title (Optional Entry) |
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MD |
1986 |
Medical School, Kapodistrean University of Athens ) |
Medicine |
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PhD |
1996 |
Medical School, Kapodistrean University of Athens |
Surgery |
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Fellow, Clinical Molecular Genetics |
1999 |
Harvard Medical School Genetics Program |
Genetics |
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Employment History
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Employment history in Academic Institutions/Research Centers – List by the three (3) most recent |
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Period of employment |
Employer |
Location |
Position |
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From |
To |
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2025 |
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MGH |
Boston, MA |
Affiliated Senior Research Scientist |
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2018 |
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BSRC Alexander Fleming |
Vari, Greece |
Affiliated Scientist |
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2003 |
2018 |
BRFAA |
Athens, Greece |
Senior Research Director |
Publications
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Key refereed journal papers, monographs, books, conference publications etc.List the five (5) more recent and other five (5) selected –(max total 10) |
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Ref. Number |
Year |
Title |
Other authors |
Journal and Publisher / |
Vol. |
Pages |
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2024 |
Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic states. |
Chim SM, Howell K, .., Karalis KP, Economides AN, Nistala H. |
Elife |
90419 |
1 |
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2022 |
Germline mutations in CIDEB and Protection against Liver Disease |
Verweij N, Haas ME, e al |
N Engl J Medicine |
28;387 (4) |
332 |
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2021 |
Sequencing of 640,000 exomes identifies GPR75 associated with protection from obesity |
Akbari P, ..,Regeneron Genetics Center; DiscovEHR Collaboration, et al |
Science |
373(6550) |
1126 |
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2021 |
Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption.
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Pediaditakis I, Kodella KR, Manatakis DV, Le CY, Hinojosa CD, Tien-Street W, Manolakos ES, Vekrellis K, Hamilton GA, Ewart L, Rubin LL, Karalis K. |
Nat Commun. |
12(1) |
590 |
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2019 |
Liver-Chip: Reproducing Human and Cross-Species Toxicities.
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Jang KJ,... Karalis KP,...Ingber D, Hamilton G.
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Sci Transl Med
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6:11 |
517 |
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2015 |
Engineered In Vitro Disease Models |
Benam K, Dauth S, …Karalis K, ..Parker KK, and Ingber DE. |
Ann Rev Pathology |
215:10 |
196
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2013 |
Corticotropin Releasing Hormone (CRH) exerts direct effects on neuronal progenitor cells: implications for neuroprotection |
Koutmani Y, Politis P , ...,Karalis KP. |
Molecular Psychiatry |
18:3 |
300 |
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2010 |
Corticotropin-Releasing Factor Regulates Tlr4 Expression in the Colon and Protects Mice from Colitis. |
Chaniotou Z, Giannogonas P, Theoharis S, …Pothoulakis C, Karalis KP. |
Gastroenterology |
139(6) |
2083 |
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1999 |
Corticotropin-Releasing Hormone unmasks the proinflammatory effects of epinephrine. |
Karalis K, Kontopoulos E, Muglia L, Majzoub JA. |
Proc Natl Acad Sci |
96 (12): |
9073 |
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1991 |
Autocrine or paracrine inflammatory actions of corticotropin-releasing hormone (CRH) in vivo |
Karalis K, Sano H, Redwine J, Listwak S, Wilder RW, Chrousos GP. |
Science |
254:42 |
1 |
Exhibitions
Research Projects
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Research Projects. List the five (5) more recent and other five (5) selected (max total 10) |
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Ref. Number |
Date |
Title |
Funded by |
Project Role* |
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2022-2025 |
Identification and validation of human genetic variants associated with protection from MeASH and liver fibrosis |
RGC |
Project Coordinator/ Section Head |
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2023-2025 |
Dissecting the role of cell-cell interactions in neuroinflammation and neuronal death in genetic Frontotemporal Dementia (FTD) |
RGC |
Project Coordinator Section Head |
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Development of a bioengineered human intestine microphysiological system (MPS) for drug development for IBD |
Takeda/ NIH |
Research and Development Head |
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2018-2021 |
Development of an in vitro human Parkinson’s disease model for identification of cell-cell interactions and biomarkers of disease progression |
NIH/ Emulate |
Research and Development Head |
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Dissecting the role of extracellular vesicles (exosomes) in the diversity of cardio-renal syndrome development in patients with heart failure- development of human in vitro models |
NIH/MGH/Emulate |
Emulate team lead in collaboration with MGH Cardiology Dpt (Prof Saumya Das) |
Academic Consulting Services/Councils/Boards/Editorial Committees
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Academic Consulting Services and/or Participation in Councils / Boards/ Editorial Committees. List the five (5) more recent (Optional Entry) |
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Ref. Number |
Period |
Organization |
Title of Position or Service |
Key Activities |
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2023-2025 |
NIH |
Study section on microphysiological systems |
Expert Reviewer |
Awards/International Recognition
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Awards / International Recognition (where applicable). List the five (5) more recent and other five (5) selected. (max total 10) (Optional Entry) |
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Ref. Number |
Date |
Title |
Awarded by: |
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9/2017 |
International Fellow Awardee |
Helmholtz Foundation, Munich, DE |
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9/2012-2014 |
Visiting Scholar |
Wyss Institute, Harvard Medical School, USA |
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2011-2020 |
Member of the Committee for European policy of EASAC on direct-to-consumer genetics testing
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EASAC |
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2009 |
Visiting Scholar, Invited ex-officio member Molecular Medicine graduate program (curriculum update and graduate committee) |
Warwick U Medical School, UK |